A null model of the mouse whole-neocortex micro-connectome.

ABSTRACT: In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale connectomics, studying connectivity between individual neurons. We combine these two complementary views of connectomics to build a first draft statistical model of the micro-connectome of a whole mouse neocortex based on available data on region-to-region connectivity and individual whole-brain axon reconstructions. This process reveals a targeting principle that allows us to predict the innervation logic of individual axons from meso-scale data. The resulting connectome recreates biological trends of targeting on all scales and predicts

SUBMITTER: Reimann MW 

PROVIDER: S-EPMC6715727 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature