Longitudinal Evaluation of Pain, Flare-Up, and Emotional Health in Fibrodysplasia Ossificans Progressiva: Analyses of the International FOP Registry.

ABSTRACT: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, inherited, connective tissue disease with ∼800 documented cases worldwide. The principal pathological feature of FOP is the transition of skeletal muscle, tendons, ligaments, and fascia into cartilage and bone. This heterotopic ossification (HO) is often preceded by painful soft tissue swellings or flare-ups that may last several months. For many individuals, experiencing a flare-up may represent a worsening of their condition and contribute to feelings of anxiety or suppressed affect, both of which are well-recognized to exacerbate pain perception. To date, much remains unknown regarding the dynamics of pain and emotional health in FOP during flare-up and also quiescent, non-flare-up disease phases. In order to elucidate the oc

SUBMITTER: Peng K 

PROVIDER: S-EPMC6715827 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature