Clinostat Rotation Affects Metabolite Transportation and Increases Organic Acid Production by Aspergillus carbonarius, as Revealed by Differential Metabolomic Analysis.

ABSTRACT: Contamination by fungi may pose a threat to the long-term operation of the International Space Station because fungi produce organic acids that corrode equipment and mycotoxins that harm human health. Microgravity is an unavoidable and special condition in the space station. However, the influence of microgravity on fungal metabolism has not been well studied. Clinostat rotation is widely used to simulate the microgravity condition in studies carried out on Earth. Here, we used metabolomics differential analysis to study the influence of clinostat rotation on the accumulation of organic acids and related biosynthetic pathways in ochratoxin A (OTA)-producing Aspergillus carbonarius As a result, clinostat rotation did not affect fungal cell growth or colony appearance but significantly incre

SUBMITTER: Jiang C 

PROVIDER: S-EPMC6715838 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature