Matrix-metalloproteinase expression and gelatinase activity in the avian retina and their influence on Muller glia proliferation.

ABSTRACT: Gelatinases are a class of matrix metalloproteinases (MMPs) that degrade the extracellular matrix (ECM) to regulate intercellular signaling and cell migration. Gelatinase activity is tightly regulated via proteolytic activation and through the expression of tissue inhibitors of matrix metalloproteinases (TIMPs). Gelatinase activity has been implicated in retinal pathophysiology in different animal models and human disease. However, the role of gelatinases in retinal regeneration remains uncertain. In this study we investigated the dynamic changes in gelatinase activity in response to excitotoxic damage and how this enzymatic activity influenced the formation of Müller glia progenitor cells (MGPCs) in the avian retina. This study used hydrogels containing a gelatinase-degradable fluorescent

SUBMITTER: Campbell WA 

PROVIDER: S-EPMC6716156 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature