Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer.

ABSTRACT:

Background

The fecal microbiome is associated with prostate cancer risk factors (obesity, inflammation) and can metabolize and produce various products that may influence cancer but have yet to be defined in prostate cancer.

Objective

To investigate gut bacterial diversity, identify specific metabolic pathways associated with disease, and develop a microbiome risk profile for prostate cancer.

Design, setting, and participants

After prospective collection of 133 rectal swab samples 2 wk before the transrectal prostate biopsy, we perform 16S rRNA amplicon sequencing on 105 samples (64 with cancer, 41 without cancer). Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was applied to infer functional categories associated with taxon

SUBMITTER: Liss MA 

PROVIDER: S-EPMC6716160 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature