Survival Associated With Sirolimus Plus Tacrolimus Maintenance Without Induction Therapy Compared With Standard Immunosuppression After Lung Transplant.

ABSTRACT:

Importance

Median survival after lung transplant is less than 6 years. Standard maintenance therapy typically includes tacrolimus and an antimetabolite (mycophenolate mofetil or azathioprine). Replacing the antimetabolite with sirolimus after postoperative wound healing may improve long-term survival due to antifibrotic, antiproliferative, and antiaging effects of sirolimus.

Objectives

To compare survival between patients receiving sirolimus plus tacrolimus vs mycophenolate mofetil plus tacrolimus (the most common maintenance therapy) and to identify the combination of induction and maintenance therapy associated with the highest survival.

Design, setting, and participants

This cohort study of US recipients of lung transplants from January 1, 2003, through August 31,

SUBMITTER: Wijesinha M 

PROVIDER: S-EPMC6716294 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature