Searching for Signatures of Cold Climate Adaptation in TRPM8 Gene in Populations of East Asian Ancestry.

ABSTRACT: Dispersal of Homo sapiens across the globe during the last 200,000 years was accompanied by adaptation to local climatic conditions, with severe winter temperatures being probably one of the most significant selective forces. The TRPM8 gene codes for a cold-sensing ion channel, and adaptation to low temperatures is the major determinant of its molecular evolution. Here, our aim was to search for signatures of cold climate adaptation in TRPM8 gene using a combined data set of 19 populations of East Asian ancestry from the 1000 Genomes Project and Human Genome Diversity Project. As a result, out of a total of 60 markers under study, none showed significant association with the average winter temperatures at the locations of the studied populations considering the multipl

SUBMITTER: Igoshin AV 

PROVIDER: S-EPMC6716346 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature