Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.

ABSTRACT: Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious worldwide health concern and a significant healthcare burden. As the majority of hypertension has an unknown etiology, considerable research efforts in both experimental models and human cohorts has focused on the premise that alterations in the fetal and perinatal environment are key factors in the development of hypertension in children and adults. The exact mechanisms of how fetal programming events increase the risk of hypertension and cardiovascular disease are not fully elaborated; however, the focus on alterations in the biochemical components and functional aspects of the renin-angiotensin (Ang) system (RAS) has predominated, particularly activation of the Ang-converting enzyme (ACE)-Ang I

SUBMITTER: South AM 

PROVIDER: S-EPMC6716381 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature