Somatostatin-Expressing Interneurons Form Axonal Projections to the Contralateral Hippocampus.

ABSTRACT: Conscious memories are critically dependent upon bilateral hippocampal formation, and interhemispheric commissural projections made by mossy cells and CA3 pyramidal cells. GABAergic interneurons also make long-range axonal projections, but little is known regarding their commissural, inter-hippocampal connections. We used retrograde and adeno-associated viral tracing, immunofluorescence and electron microscopy, and in vitro optogenetics to assess contralateral projections of neurochemically defined interneuron classes. We found that contralateral-projecting interneurons were 24-fold less common compared to hilar mossy cells, and mostly consisted of somatostatin- and parvalbumin-expressing types. Somatostatin-expressing cells made denser contralateral axonal projections than parvalbumin-exp

SUBMITTER: Eyre MD 

PROVIDER: S-EPMC6716454 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature