Early Pain Exposure Influences Functional Brain Connectivity in Very Preterm Neonates.

ABSTRACT:

Background

Early exposure to nociceptive events may cause brain structural alterations in preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little is known on the extent to which early pain may affect brain connectivity. We aim to evaluate brain functional connectivity changes in preterm neonate that underwent multiple invasive procedures during the postnatal period, and to correlate them with the neurodevelopmental outcome at 24 months.

Methods

In this prospective case-control study, we collected information about exposure to painful events during the early postnatal period and resting-state BOLD-fMRI data at term equivalent age from two groups of preterm neonate: 33 subjected to painful procedures during the neonatal intensive care (mean gesta

SUBMITTER: Tortora D 

PROVIDER: S-EPMC6716476 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature