Risk factors for chronic lung disease and asthma differ among children born extremely preterm.

ABSTRACT:

Objectives

To evaluate the hypothesis that chronic lung disease of prematurity (CLD) is a risk factor for asthma in children born extremely preterm, and the hypothesis that the risk factors for CLD are similar to those for asthma.

Methods

A retrospective analysis was performed using data collected prospectively from 882 children born before the 28th week of gestation between 2002 and 2004 who returned for follow-up at ages 12 and 24 months and 10 years. We created time-oriented logistic regression models to compare risk factors for CLD, defined as need for supplemental oxygen at 36 weeks postmenstrual age, and parent-reported asthma at 10 years of age.

Results

CLD diagnosed during neonatal admission was associated with bronchodilator use at 12 months and 24 months (P 

SUBMITTER: Jackson WM 

PROVIDER: S-EPMC6716602 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature