Inflammation time-axis in aseptic loosening of total knee arthroplasty: A preliminary study.

ABSTRACT:

Objective

Aseptic loosening (AL) is the most frequent long-term reason for revision of total knee arthroplasty (TKA) affecting about 15-20% patients within 20 years after the surgery. Although there is a solid body of evidence about the crucial role of inflammation in the AL pathogenesis, scared information on inflammation signature and its time-axis in tissues around TKA exists.

Design

The inflammation protein signatures in pseudosynovial tissues collected at revision surgery from patients with AL (AL, n = 12) and those with no clinical/radiographic signs of AL (non-AL, n = 9) were investigated by Proximity Extension Assay (PEA)-Immunoassay and immunohistochemistry.

Results

AL tissues had elevated levels of TNF-family members sTNFR2, TNFSF14, sFasL, sBAFF, cytokines/

SUBMITTER: Dyskova T 

PROVIDER: S-EPMC6716666 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature