Antiplatelet therapy and coronary artery bypass grafting: Protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Saphenous vein graft (SVG) is the most common conduit used for coronary artery bypass grafting (CABG) surgery. Unfortunately, SVG are associated with poor long-term patency rates; a significant predictor of re-operation rates and survival. As such, medical therapy to prevent SVG narrowing or occlusion is of paramount importance. Aspirin (ASA) monotherapy is the standard of care after CABG, to improve long-term major adverse cardiovascular events (MACE) and graft patency. Benefits of dual antiplatelet therapy (DAPT) have not been well established in all CABG patients. We present a protocol for a network meta-analysis (NMA) comparing the effects of various antiplatelet therapy regimens on SVG patency, mortality, and bleeding among adult patients following CABG.

Method

SUBMITTER: Gupta S 

PROVIDER: S-EPMC6716708 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature