Impact of prior malignancies on outcome of colorectal cancer; revisiting clinical trial eligibility criteria.

ABSTRACT:

Background

Most clinical trials on colorectal cancer (CRC) exclude cases who have history of a prior malignancy. However, no prior research studied this history's actual impact on the survival of CRC. In the paper, we study the effects of having a malignancy preceding CRC diagnosis on its survival outcomes.

Methods

CRC patients diagnosed during 1973-2008 were reviewed using the SEER 18 database. We calculated overall survival and cancer-specific survival of subsequent CRC, and more specifically stage IV CRC, using Kaplan-Meier test and adjusted Cox models.

Results

A total 550,325 CRC patients were reviewed, of whom 31,663 had history of a prior malignancy. The most commonly reported sites of a prior malignancy were: prostate, breast, urinary bladder, lung, and endomet

SUBMITTER: Al-Husseini MJ 

PROVIDER: S-EPMC6716811 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature