Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis.

ABSTRACT:

Background

Stromal interaction molecule (STIM) 2 is a key calcium-sensing molecule that regulates the stabilization of calcium ions (Ca²⁺) and therefore regulates downstream Ca²⁺-associated signaling and cellular events. We hypothesized that STIM2 regulates epithelial-mesenchymal transition (EMT) to promote breast cancer metastasis.

Methods

We determined the effects of gain, loss, and rescue of STIM2 on cellular motility, levels of EMT-related proteins, and secretion of transforming growth factor-β (TGF-β). We also conducted bioinformatics analyses and in vivo assessments of breast cancer growth and metastasis using xenograft models.

Results

We found a significant association between STIM2 overexpression and metastatic breast cancer. STIM2 overex

SUBMITTER: Miao Y 

PROVIDER: S-EPMC6716836 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature