Identification of discriminatory antibiotic resistance genes among environmental resistomes using extremely randomized tree algorithm.

ABSTRACT:

Background

The interconnectivities of built and natural environments can serve as conduits for the proliferation and dissemination of antibiotic resistance genes (ARGs). Several studies have compared the broad spectrum of ARGs (i.e., "resistomes") in various environmental compartments, but there is a need to identify unique ARG occurrence patterns (i.e., "discriminatory ARGs"), characteristic of each environment. Such an approach will help to identify factors influencing ARG proliferation, facilitate development of relative comparisons of the ARGs distinguishing various environments, and help pave the way towards ranking environments based on their likelihood of contributing to the spread of clinically relevant antibiotic resistance. Here we formulate and demonstrate an approach us

SUBMITTER: Gupta S 

PROVIDER: S-EPMC6716844 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature