Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis.

ABSTRACT:

Background

Although several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, -509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection.

Methods

The summary odds ratios (ORs) of chronic HCV infected patients and controls with all SNPs were obtained by adaptive fixed or random effect model. A series of statistical tools were employed to guarantee the accuracy of related pooling ORs, including the Hardy-Weinberg equilibrium (HWE) test, sensitivity analysis a

SUBMITTER: Guo P 

PROVIDER: S-EPMC6716859 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature