MFG-E8 mediates arterial aging by promoting the proinflammatory phenotype of vascular smooth muscle cells.

ABSTRACT:

Background

Among older adults, arterial aging is the major factor contributing to increased risk for cardiovascular disease-related morbidity and mortality. The chronic vascular inflammation that accompanies aging causes diffuse intimal-medial thickening of the arterial wall, thus increasing the vulnerability of aged vessels to vascular insults. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a biomarker for aging arteries. This integrin-binding glycoprotein, induced by angiotensin II, facilitates vascular smooth muscle cell (VSMC) proliferation and invasion in aging vasculatures. This study investigated whether MFG-E8 directly mediates the initial inflammatory responses in aged arteries or VSMCs.

Methods

A model of neointimal hyperplasia was induced in the common car

SUBMITTER: Chiang HY 

PROVIDER: S-EPMC6716880 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature