The association between BRAF mutation class and clinical features in BRAF-mutant Chinese non-small cell lung cancer patients.

ABSTRACT:

Background

BRAF mutations occur in 2-4% non-small cell lung cancer (NSCLC) patients and can be categorized into three functional classes based on signaling mechanism and kinase activity: RAS-independent kinase-activating V600 monomers (class 1), RAS-independent kinase-activating dimers (class 2) and RAS-dependent kinase-inactivating heterodimers (class 3). The association between functional classes and clinical features in Chinese NSCLC patients remains unexplored. Our multi-center study aimed to survey the BRAF mutation rate and analyze the associated clinical features in this population.

Methods

Capture-based sequencing data of either plasma or tissue samples obtained from 8405 Chinese stage I-IV NSCLC patients were retrospectively analyzed.

Results

BRAF mutations w

SUBMITTER: Lin Q 

PROVIDER: S-EPMC6716889 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature