Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma.

ABSTRACT:

Background

The five-year survival rate and therapeutic effect of malignant glioma is low. Identification of key/associated proteins and pathways in glioma is necessary for developing effective diagnosis and targeted therapy of glioma. In addition, Glioma involves hypoxia-specific microenvironment, whether hypoxia restriction influences the stoichioproteomic characteristics of expressed proteins is unknown.

Methods

In this study, we analyzed the most comprehensive immunohistochemical data from 12 human glioma samples and 4 normal cell types of cerebral cortex, identified differentially expressed proteins (DEPs), and researched the oxygen contents of DEPs, highly and lowly expressed proteins. Further we located key genes on human genome to determine their locations and enriche

SUBMITTER: Yin Y 

PROVIDER: S-EPMC6716898 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature