Breast cancer histologic subtypes show excess familial clustering.

ABSTRACT: BACKGROUND:The inherited predisposition to developing specific histologic subtypes of invasive breast carcinoma has been incompletely investigated. By using a large, population-based database, the authors sought to investigate familial clustering of breast cancer by histologic subtype. METHODS:By using the Utah Population Database, which links genealogy records to the National Cancer Institute's statewide Surveillance, Epidemiology, and End Results cancer registry, the authors identified patients with breast cancer by histology and tested for evidence of shared genetic predisposition to histologic specific subtypes by examining pairwise relatedness and estimating the relative risk (RR) among first-degree, second-degree, and third-degree relatives. RESULTS:The authors identified 23,629 indi

SUBMITTER: Henry NL 

PROVIDER: S-EPMC6716995 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature