In vivo validation of T2- and susceptibility-based S_v O₂ measurements with jugular vein catheterization under hypoxia and hypercapnia.

ABSTRACT: PURPOSE:To investigate the mutual agreement of T2-based and susceptibility-based methods as well as their agreement with jugular catheterization, for quantifying venous oxygen saturation (S_v O₂ ) at a broad range of brain oxygenation levels. METHODS:S_v O₂ measurements using T2-relaxation-under-spin-tagging (TRUST) and susceptibility-based oximetry (SBO) were performed in 13 healthy subjects under room air, hypoxia, and hypercapnia conditions. Agreement between TRUST and SBO was quantitatively evaluated. In two of the subjects, TRUST and SBO were compared against the clinical gold standard, co-oximeter measurement via internal jugular vein catheterization. RESULTS:Absolute S_v O₂ measurements using TRUST and SBO were highly co

SUBMITTER: Miao X 

PROVIDER: S-EPMC6717011 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature