Toxicogenomic analysis of publicly available transcriptomic data can predict food, drugs, and chemical-induced asthma.

ABSTRACT:

Background

: With the increasing incidence of asthma, more attention is focused on the diverse and complex nutritional and environmental triggers of asthma exacerbations. Currently, there are no established risk assessment tools to evaluate asthma triggering potentials of most of the nutritional and environmental triggers encountered by asthmatic patients.

Purpose

 The objective of this study is to devise a reliable workflow, capable of estimating the toxicogenomic effect of such factors on key player genes in asthma pathogenesis.

Methods

Gene expression extracted from publicly available datasets of asthmatic bronchial epithelium were subjected to a comprehensive analysis of differential gene expression to identify significant genes involved in asthma development and

SUBMITTER: Hachim MY 

PROVIDER: S-EPMC6717055 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature