Landscape of Enhancer-Enhancer Cooperative Regulation during Human Cardiac Commitment.

ABSTRACT: Although accumulating evidence has demonstrated the key roles of enhancers in gene expression regulation, the contribution of genome-wide enhancer-enhancer interactions to developmental decisions remains unclear. Here we explored the cooperative regulation patterns among enhancers to understand their regulatory mechanism. We first filtered robust enhancers in embryonic stem cells (ESCs) through integrating bidirectional transcription, genomic location, and epigenetic modification. Genome-wide enhancer-enhancer interactions were then identified based on enhancer-promoter relationships that were derived from Hi-C data. We further explored the interacting principles of the identified enhancer-enhancer interactions. The results revealed that the observed cooperativity occurred mainly between e

SUBMITTER: Chen H 

PROVIDER: S-EPMC6717080 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature