Prospective Multicentered Safety and Feasibility Pilot for Endobronchial Intratumoral Chemotherapy.

ABSTRACT:

Background

Malignant airway obstruction (MAO) occurs in 30% of patients with advanced-stage lung cancer, leading to debilitating dyspnea, cough, and hemoptysis. Other than recanalization of the airways, these patients lack long-lasting palliative therapy. The goal of this study was to determine the safety and feasibility of local injection of paclitaxel into the airway wall with a novel microinjection catheter.

Methods

In this multicentered prospective trial, 23 patients with non-small cell lung cancer and MAO were enrolled from July 2014 through June 2016 to undergo rigid bronchoscopy with recanalization, followed by injection of 1.5 mg of paclitaxel with a novel injection catheter. Primary end points consisted of safety (adverse events, severe adverse events, and unanticip

SUBMITTER: Yarmus L 

PROVIDER: S-EPMC6717117 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature