Spreading of perturbations in myosin group kinetics along actin filaments.

ABSTRACT: Global changes in the state of spatially distributed systems can often be traced back to perturbations that arise locally. Whether such local perturbations grow into global changes depends on the system geometry and the spatial spreading of these perturbations. Here, we investigate how different spreading behaviors of local perturbations determine their global impact in 1-dimensional systems of different size. Specifically, we assessed sliding arrest events in in vitro motility assays where myosins propel actin, and simulated the underlying mechanochemistry of myosins that bind along the actin filament. We observed spontaneous sliding arrest events that occurred more frequently for shorter actin filaments. This observation could be explained by spontaneous local arrest of myosin kinetics t

SUBMITTER: Balassy Z 

PROVIDER: S-EPMC6717291 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature