Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation.

ABSTRACT:

Background

Environmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. We assessed the association between the urinary concentrations of 11 phthalate metabolites and BPA with length of gestation in a cohort of women followed from before conception with daily 1st-morning urinary hormone measures that identified day of implantation.

Methods

Pre-implantation and post-implantation urinary phthalate metabolites and BPA concentrations were measured in pooled urine samples designed to limit single-measure variability due to the likely episodic nature of these exposures and the short half-life of these compounds. We estimated associations between these exposure biomarkers early in pregnancy with length of gestation

SUBMITTER: Chin HB 

PROVIDER: S-EPMC6717338 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature