All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling.

ABSTRACT:

Background and purpose

Regulation of neural inflammation is considered as a vital therapeutic target in ischemic stroke. All-trans retinoic acid (atRA), a potent immune modulator, has raised interest in the field of stroke therapy. However, the immunological mechanisms for atRA-mediated neuroprotection remain elusive. The current study evaluated the impact of atRA on post-stroke neural inflammation and elucidated the mechanisms involved in the regulation of related neutrophil functions.

Methods

atRA was prophylactically administered to mice 1 day before transient middle cerebral artery occlusion (tMCAO, 1 h) and repeated daily immediately after reperfusion for 3 days. Stroke outcomes, neutrophil polarization, and formation of neutrophil extracellular traps (NETs) in the stro

SUBMITTER: Cai W 

PROVIDER: S-EPMC6717357 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature