Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3 T3-L1 cells.

ABSTRACT:

Background

Loss of ovarian function, as in menopause or after ovariectomy (OVX), is closely associated with obesity and white adipose tissue (WAT) inflammation. Estrogen replacement protects against postmenopausal obesity but increases the risks of carcinogenesis. In the present study, we investigated the effects of long-term treatment of raloxifene (RAL), a selective estrogen receptor modulator, on the features of estrogen deficiency-induced obesity and explored the involvement of canonical and non-canonical Wnt regulation in vivo and in vitro.

Methods

Adult female rats received bilateral OVX and divided into 5 groups: (1) Sham, (2) OVX, (3) OVX + E₂: OVX rats were administered with E₂ (50 μg/kg, s.c., 3 times/week), (4) OVX + RAL: OVX rats were treate

SUBMITTER: Shen HH 

PROVIDER: S-EPMC6717377 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature