Outcomes associated with dual antiplatelet therapy after myocardial infarction in patients with aortic stenosis.

ABSTRACT: BACKGROUND:Acquired loss of the largest von Willebrand factor multimers is a common hemostatic disturbance in patients with aortic valve stenosis (AS), resulting in impaired platelet adhesion and increased bleeding risk. AS is also associated with atherosclerosis and myocardial infarction (MI). Our aim was to study the clinical outcomes associated with AS in MI patients treated with dual antiplatelet therapy (DAPT) in a nationwide hospital-based register study. METHODS:Based on nationwide hospital discharge registers from Sweden (2005-2010) and Denmark (2005-2015), we calculated 1-year incidence rates and hazard ratios of bleeding, recurrent MI, and all-cause mortality in MI patients with and without AS treated with DAPT. Results from both countries were also combined in a meta-analysis. R

SUBMITTER: Martinsson A 

PROVIDER: S-EPMC6717510 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature