Mathematical modeling of the heterogeneous distributions of nanomedicines in solid tumors.

ABSTRACT: The distribution of nanomedicines inside solid tumors is often restricted to perivascular areas, leaving most distal tumor cells out of reach. This partly explains modest patient benefit of many nanomedicines compared to their free-form counterparts. The objective for this study is to develop a mathematical model to quantitatively analyze this phenomenon and the influencing factors to such perivascular distribution and seek for effective strategies to alleviate this. A spatial tumor distribution model was firstly constructed to mimic the geometrical structure of tumor vessels and the surrounding tumor cells. This tumor model was further integrated with a systemic pharmacokinetics model for nanoparticles. A variety of factors on the tumor spatial distributions of nanomedicines were consider

SUBMITTER: He H 

PROVIDER: S-EPMC6717548 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature