Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity.

ABSTRACT: Chronic lymphocytic leukemia cells have an altered energy metabolism compared to normal B cells. While there is a growing understanding of the molecular heterogeneity of the disease, the extent of metabolic heterogeneity and its relation to molecular heterogeneity has not been systematically studied. Here, we assessed 11 bioenergetic features, primarily reflecting cell oxidative phosphorylation and glycolytic activity, in leukemic cells from 140 chronic lymphocytic leukemia patients using metabolic flux analysis. We examined these bioenergetic features for relationships with molecular profiles (including genetic aberrations, transcriptome and methylome profiles) of the tumors, their ex vivo responses to a panel of 63 compounds, and with clinical data. We observed that leukemic cells

SUBMITTER: Lu J 

PROVIDER: S-EPMC6717593 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature