Targeting B-cell malignancies with the beta-emitting anti-CD37 radioimmunoconjugate ¹⁷⁷Lu-NNV003.

ABSTRACT:

Purpose

The aim of this study was to explore the β-emitting lutetium-177 labelled anti-CD37 antibody NNV003 (¹⁷⁷Lu-NNV003, Humalutin®) for the treatment of non-Hodgkin's lymphoma in in vitro studies and in animal models.

Methods

Cytotoxicity of ¹⁷⁷Lu-NNV003 was measured in REC-1 (mantle cell lymphoma) and DOHH-2 (diffuse large B cell lymphoma) cell lines. Biodistribution was studied in mice bearing subcutaneous DOHH-2 or MEC-2 (chronic lymphocytic leukaemia) xenografts. The therapeutic effect of a single injection of ¹⁷⁷Lu-NNV003 was measured in mice intravenously or subcutaneously injected with REC-1 cells. Haematological and histopathological assessments were used to evaluate the toxic effect of ¹⁷⁷Lu-NNV003. The immunotherapeuti

SUBMITTER: Maaland AF 

PROVIDER: S-EPMC6717602 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature