A step towards clinical application of acellular matrix: A clue from macrophage polarization.

ABSTRACT: The outcome of tissue engineered organ transplants depends on the capacity of the biomaterial to promote a pro-healing response once implanted in vivo. Multiple studies, including ours, have demonstrated the possibility of using the extracellular matrix (ECM) of animal organs as platform for tissue engineering and more recently, discarded human organs have also been proposed as scaffold source. In contrast to artificial biomaterials, natural ECM has the advantage of undergoing continuous remodeling which allows adaptation to diverse conditions. It is known that natural matrices present diverse immune properties when compared to artificial biomaterials. However, how these properties compare between diseased and healthy ECM and artificial scaffolds has not yet been defined. To answer this qu

SUBMITTER: Petrosyan A 

PROVIDER: S-EPMC6717660 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature