Subcutaneous nerve stimulation for rate control in ambulatory dogs with persistent atrial fibrillation.

ABSTRACT:

Background

Subcutaneous nerve stimulation (ScNS) damages the stellate ganglion and improves rhythm control of atrial fibrillation (AF) in ambulatory dogs.

Objective

The purpose of this study was to test the hypothesis that thoracic ScNS can improve rate control in persistent AF.

Methods

We created persistent AF in 13 dogs and randomly assigned them to ScNS (n = 6) and sham control (n = 7) groups. ¹⁸F-2-Fluoro-2-deoxyglucose positron emission tomography/magnetic resonance imaging of the brain stem was performed at baseline and at the end of the study.

Results

The average stellate ganglion nerve activity reduced from 4.00 ± 1.68 μV after the induction of persistent AF to 1.72 ± 0.42 μV (P = .032) after ScNS. In contrast, the average stellate ganglion n

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC6717670 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature