An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets.

ABSTRACT: Atrioventricular heart valves (AHVs) are composed of structurally complex and morphologically heterogeneous leaflets. The coaptation of these leaflets during the cardiac cycle facilitates unidirectional blood flow. Valve regurgitation is treated preferably by surgical repair if possible or replacement based on the disease state of the valve tissue. A comprehensive understanding of valvular morphology and mechanical properties is crucial to refining computational models, serving as a patient-specific diagnostic and surgical tool for preoperative planning. Previous studies have modeled the stress distribution throughout the leaflet's thickness, but validations with layer-specific biaxial mechanical experiments are missing. In this study, we sought to fill this gap in literature by investigat

SUBMITTER: Kramer KE 

PROVIDER: S-EPMC6717680 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature