Diabetes-mediated promotion of colon mucosa carcinogenesis is associated with mitochondrial dysfunction.

ABSTRACT: Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of cancer, including colon cancer (CC). However, we recently reported no influence of T2DM on CC prognosis, suggesting that any effect might be at the early stages of tumor development. We hypothesized that T2DM may create an environment in the healthy tissue, which acts as a carcinogenesis driver in agreement with the field of cancerization concept. Here, we focused on early carcinogenesis by analyzing paired tumor and normal colonic mucosa samples from the same patients. The proteome of CC and paired mucosa was quantitatively analyzed in 28 individuals (12 diabetics and 16 nondiabetics) by mass spectrometry with isobaric labeling. Out of 3076 identified proteins, 425 were differentially expressed at the tumor in d

SUBMITTER: Del Puerto-Nevado L 

PROVIDER: S-EPMC6717745 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature