Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study.

ABSTRACT:

Aims/introduction

We examined a prospective association between serum creatinine levels and diabetes.

Materials and methods

The present study included 31,343 male workers without diabetes, and aged between 20 and 64 years at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either glycated hemoglobin levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL or receiving antidiabetic treatment. Cox proportional hazards regression analysis was carried out to estimate the hazard ratio (HR) and 95% confidence interval (CI).

Results

With a median observation of 7.7 years, 2,509 participants developed diabetes. After adjusting for age, smoking, body mass index, hypertension and dysl

SUBMITTER: Hu H 

PROVIDER: S-EPMC6717816 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature