Selective activation of G_s signaling in adipocytes causes striking metabolic improvements in mice.

ABSTRACT:

Objective

Given the worldwide epidemics of obesity and type 2 diabetes, novel antidiabetic and appetite-suppressing drugs are urgently needed. Adipocytes play a central role in the regulation of whole-body glucose and energy homeostasis. The goal of this study was to examine the metabolic effects of acute and chronic activation of G_s signaling selectively in adipocytes (activated G_s stimulates cAMP production), both in lean and obese mice.

Methods

To address this question, we generated a novel mutant mouse strain (adipo-GsD mice) that expressed a G_s-coupled designer G protein-coupled receptor (Gs DREADD or short GsD) selectively in adipocytes. Importantly, the GsD receptor can only be activated by administration of an exogenous agent (CNO) th

SUBMITTER: Wang L 

PROVIDER: S-EPMC6717953 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature