On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B.

ABSTRACT:

Background

Non-invasive evaluation for liver fibrosis is clinically important, especially in patients with undetectable hepatitis B virus (HBV) DNA treated with nucleoside analogs.

Aim

To clarify the monitoring power of hepatitis B core-related antigen (HBcrAg) for hepatic histologic changes in patients with chronic hepatitis B (CHB) treated with entecavir.

Methods

This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression, respectively, in 403 CHB patients, including 374 with entecavir for 72 weeks (291 underwent paired liver biopsy) and 29 as controls.

Results

Level of HBcrAg correlated negatively with liver fibrosis sta

SUBMITTER: Chang XJ 

PROVIDER: S-EPMC6718032 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature