Ontology highlight
ABSTRACT:
SUBMITTER: Liang D
PROVIDER: S-EPMC6718324 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20190615
The DNA alkylating prodrug cyclophosphamide (CPA), alone or in combination with other agents, is one of the most commonly used anti-cancer agents. As a prodrug, CPA is activated by cytochrome P450 2B6 (CYP2B6), which is transcriptionally regulated by the human constitutive androstane receptor (hCAR). Therefore, hCAR agonists represent novel sensitizers for CPA-based therapies. Among known hCAR agonists, compound 6-(4-chlorophenyl)imidazo-[2,1-b]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime ...[more]