Environmental variables that ameliorate extinction learning deficits in the 129S1/SvlmJ mouse strain.

ABSTRACT: Fear conditioning is an associative learning process by which organisms learn to avoid environmental stimuli that are predictive of aversive outcomes. Fear extinction learning is a process by which avoidance of fear-conditioned stimuli is attenuated when the environmental stimuli is no longer predictive of the aversive outcome. Aberrant fear conditioning and extinction learning are key elements in the development of several anxiety disorders. The 129S1 inbred strain of mice is used as an animal model for maladaptive fear learning because this strain has been shown to generalize fear to other nonaversive stimuli and is less capable of extinguishing fear responses relative to other mouse strains, such as the C57BL/6. Here we report new environmental manipulations that enhance fear and extinc

SUBMITTER: Cazares VA 

PROVIDER: S-EPMC6718342 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature