Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts.

ABSTRACT: Lysophosphatidylcholine (LPC) may accumulate in the heart to cause fibrotic events, which is mediated through fibroblast activation and collagen accumulation. Here, we evaluated the mechanisms underlying LPC-mediated collagen induction via mitochondrial events in human cardiac fibroblasts (HCFs), coupling application of the pharmacologic cyclooxygenase-2 (COX-2) inhibitor, celecoxib, and genetic mutations in FOXO1 on the fibrosis pathway. In HCFs, LPC caused prostaglandin E₂ (PGE₂)/PGE₂ receptor 4 (EP₄)-dependent collagen induction via activation of transcriptional activity of forkhead box protein O1 (FoxO1) on COX-2 gene expression. These responses were mediated through LPC-induced generation of mitochondrial reactive oxygen species (mito

SUBMITTER: Tseng HC 

PROVIDER: S-EPMC6718437 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature