The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases.

ABSTRACT: Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise regulation of cell positioning. CXCR4 is one of the most studied chemokine receptors and is involved in many functions beyond leukocyte recruitment. During embryogenesis, it plays essential roles in vascular development, hematopoiesis, cardiogenesis, and nervous system organization. It has been also implicated in tumor progression and autoimmune diseases and, together with CD4, is one of the co-receptors used by the HIV-1 virus to infect immune cells. In contrast to other chemokine receptors that are characterized by ligand promiscuity, CXCR4 has a

SUBMITTER: Garcia-Cuesta EM 

PROVIDER: S-EPMC6718456 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature