Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress.

ABSTRACT: In mammals, recombination activating gene 1 (RAG1) plays a crucial role in adaptive immunity, generating a vast range of immunoglobulins. Rag1^-/- zebrafish (Danio rerio) are viable and reach adulthood without obvious signs of infectious disease in standard nonsterile conditions, suggesting that innate immunity could be enhanced to compensate for the lack of adaptive immunity. By using microarray analysis, we confirmed that the expression of immunity- and apoptosis-related genes was increased in the rag1^-/- fish. This tool also allows us to notice alterations of the DNA repair and cell cycle mechanisms in rag1^-/- zebrafish. Several senescence and aging markers were analyzed. In addition to the lower lifespan of rag1^-/- zebrafish compared to their

SUBMITTER: Novoa B 

PROVIDER: S-EPMC6718522 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature