The establishment of immune infiltration based novel recurrence predicting nomogram in prostate cancer.

ABSTRACT: Prostate cancer (PCa), a severe health burden for males, accounts for the second frequent cancer and fifth tumor specific death cancer around the world. Several studies on tumor-infiltrating immune cells (TIICs) have shown inconsistent and controversial results to PCa. We downloaded a gene expression matrix and clinical information from TCGA, and CIBERSORT was used to identify the proportion of TIICs. Wilcoxon's Sign Rank Test evaluated different gene expression levels in PCa and normal tissues. Kaplan-Meier curves were used to evaluate the associations of TIICs and recurrence-free survival (RFS). Finally, based on the preset P-value of .05, the distribution of TIICs in 73 PCa tissues and 11 normal tissues was illustrated. Activated CD4⁺ T cells and M0 macrophages account for a

SUBMITTER: Meng J 

PROVIDER: S-EPMC6718526 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature