Colitis after checkpoint blockade: A retrospective cohort study of melanoma patients requiring admission for symptom control.

ABSTRACT:

Background

Immune checkpoint inhibitors (CPIs) have revolutionized oncologic therapy but can lead to immune-related adverse events (irAEs). Corticosteroids are first-line treatment with escalation to biologic immunosuppression in refractory cases. CPI-related gastroenterocolitis (GEC) affects 20%-50% of patients receiving CPIs and can carry significant morbidity and mortality. Severe CPI-related GEC is not well-described. We present the clinical characterization of all CPI-related GEC requiring admission at a single institution.

Methods

Clinical, laboratory, radiographic, and endoscopic data were extracted from charts of all melanoma patients ≥18 years of age admitted to one institution for CPI-related GEC, from February 5, 2011 to December 13, 2016. Patients were followed u

SUBMITTER: Hughes MS 

PROVIDER: S-EPMC6718531 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature