Augmentation of cellular NAD⁺ by NQO1 enzymatic action improves age-related hearing impairment.

ABSTRACT: Age-related hearing loss (ARHL) is a major neurodegenerative disorder and the leading cause of communication deficit in the elderly population, which remains largely untreated. The development of ARHL is a multifactorial event that includes both intrinsic and extrinsic factors. Recent studies suggest that NAD⁺ /NADH ratio may play a critical role in cellular senescence by regulating sirtuins, PARP-1, and PGC-1α. Nonetheless, the beneficial effect of direct modulation of cellular NAD⁺ levels on aging and age-related diseases has not been studied, and the underlying mechanisms remain obscure. Herein, we investigated the effect of β-lapachone (β-lap), a known plant-derived metabolite that modulates cellular NAD⁺ by conversion of NADH to NAD⁺ via the

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC6718544 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature