Development and validation of a prognostic model for patients with hepatocellular carcinoma undergoing radiofrequency ablation.

ABSTRACT:

Background

There are large variations in prognosis among hepatocellular carcinoma (HCC) patients undergoing radiofrequency ablation (RFA). However, current staging or scoring systems hardly discriminate the outcome of HCC patients treated with RFA.

Methods

A total of 757 treatment-naïve HCC patients undergoing RFA (derivation cohort) were analyzed to establish a nomogram for disease-free survival (DFS) based on Cox proportional hazard regression model. Accuracy of the nomogram was assessed and compared with conventional staging or scoring systems. Furthermore, external validation was performed in an independent cohort including 208 patients (validation cohort).

Results

Tumor size, tumor number, alpha-fetoprotein, prothrombin induced by vitamin K absence-II, lymphocyte

SUBMITTER: Kim CG 

PROVIDER: S-EPMC6718586 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature