The association of Q472H variant in the KDR gene with recurrent pregnancy loss in Southern Iran: A case-control study.

ABSTRACT:

Background

Recurrent spontaneous abortion (RSA) often remains unclear and can be burden for the patient and time consuming for clinician. RSA may initiates from a genetic or non-genetic factors. It is well known that the quality of placental circulation is critical for implantation and embryo development. Because of angiogenic effects of VEGF-KDR pathway on placenta, the genes involved in this pathway (the KDR or VEGFR genes) are thought to be linked with RSA.

Objective

The aim of this study was to investigate the relationship between Gln472His (A/T) polymorphism of the KDR gene with RSAs in southern Iran.

Materials and methods

In this case-control study, 50 aborted embryonic tissue obtained from fetuses and 50 umbilical cord blood of newborn babi

SUBMITTER: Keshavarz L 

PROVIDER: S-EPMC6718886 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature